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Malassezia diseases and saturated fats

Malassezia have lost a gene* required to completely burn unsaturated fats—but they can burn saturated fats without issue. This means they...

Malassezia are picky eaters

Malassezia are very picky eaters. They can’t grow if given only short fatty acids, probably because they can’t elongate them to build...

Malassezia diseases and body fat

Malassezia are lipid dependent fungi which require human fat to grow in our bodies. This is quite unusual for fungi: all other medically...

Parkinson's and lipids

Many lipid metabolism alleles are risk factors of Parkinson’s disease (Xicoy 2019). Individuals who inherit non-functional GBA variants...

Parkinson's and seborrheic dermatitis

Seborrheic dermatitis is a type of skin inflammation caused by overgrowth of Malassezia (Borda 2015). It has long been known to be...

Parkinson's and HIV/AIDS

To keep commensal microbes in check and fight off infections, our immune system relies heavily on helper T cells. In the Parkinson’s...

External validation: Aykut et al 2019

In 2012, the discovery that PSP94 was a fungicidal protein firmly pointed to a fungal cause for prostate cancer (Stott-Miller 2013,...

MAP causes Crohn's disease, but...

Mycobacterium avium subspecies paratuberculosis (MAP) is an important trigger for Crohn’s disease. However, most Crohn’s patients don’t...

External validation: Limon et al 2019

An article published this week in Cell Host & Microbe has provided the first strong external validation that Malassezia cause Crohn's...

PSP94, fungi and prostate cancer

The PSP94 Project started at the beginning of 2012, when it was discovered that a human protein called PSP94 is a potent fungicide...

Back pain in men vs. women (AS-type)

This post is a detailed explanation of the animated back pain video. Back pain (AS-type) Ankylosing spondylitis (AS) is a common type of...

Chronic back pain (AS-type)

A severe form of chronic inflammatory back pain is called ankylosing spondylitis (AS), where damage to joints separating vertebrae can be...

Crohn's + vedolizumab = psoriasis

T cells originating in the gut can cause psoriasis T cells in psoriatic skin often originate in the gut. We know this because they...

Psoriasis and Candida

Psoriasis and Candida: the problem In 1925, Fleisher and Wachowiak discovered that psoriasis patients had high rates of Candida in their...

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